New Publications
2023
Kornienko J, Rodríguez-Martínez M, Fenzl K, Hinze F, Schraivogel D, Grosch M, Tunaj B, Lindenhofer D, Schraft L, Kueblbeck M, Smith E, Mao C, Brown E, Owens A, Saguner AM, Meder B, Parikh V, Gotthardt M, Steinmetz LM. Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3. Nat Commun. 2023 Jul 18;14(1):4312. doi: 10.1038/s41467-023-39965-6. PMID: 37463913; PMCID: PMC10353998.
Grosch M, Schraft L, Chan A, Küchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Krämer C, Clauder-Münster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. PMID: 37349314; PMCID: PMC10287752.
Reich C, Meder B. The Heart and Artificial Intelligence-How Can We Improve Medicine Without Causing Harm. Curr Heart Fail Rep. 2023 Aug;20(4):271-279. doi: 10.1007/s11897-023-00606-0. Epub 2023 Jun 9. PMID: 37291432; PMCID: PMC10250175.
Petersen M, Schmiedel N, Dierck F, Hille S, Remes A, Senger F, Schmidt I, Lüllmann-Rauch R, Müller OJ, Frank D, Rangrez AY, Frey N, Kuhn C. Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo. Front Mol Biosci. 2023 Jun 5; 10:1169658. doi: 10.3389/fmolb.2023.1169658. PMID: 37342207; PMCID: PMC10278231.
Oeing CU, Pepin ME, Saul KB, Agircan AS, Assenov Y, Merkel TS, Sedaghat-Hamedani F, Weis T, Meder B, Guan K, Plass C, Weichenhan D, Siede D, Backs J. Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure. Basic Res Cardiol. 2023 Mar 20;118(1):9. doi: 10.1007/s00395-022-00954-3. PMID: 36939901; PMCID: PMC10027651.
Wang Y, Dobreva G. Epigenetics in LMNA-Related Cardiomyopathy. Cells. 2023 Mar 1;12(5):783. doi: 10.3390/cells12050783. PMID: 36899919; PMCID: PMC10001118.
Cavalheiro GR, Girardot C, Viales RR, Pollex T, Cao TBN, Lacour P, Feng S, Rabinowitz A, Furlong EEM. CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles. Sci Adv. 2023 Feb 3;9(5): eade1085. doi: 10.1126/sciadv.ade1085. Epub 2023 Feb 3. PMID: 36735786; PMCID: PMC9897672.
2022
Poetz F, Lebedeva S, Schott J, Lindner D, Ohler U, Stoecklin G. Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation. Genome Biol. 2022 Sep 12;23(1):193. doi: 10.1186/s13059-022-02760-5. PMID: 36096941; PMCID: PMC9465963.
Tappu R, Haas J, Lehmann DH, Sedaghat-Hamedani F, Kayvanpour E, Keller A, Katus HA, Frey N, Meder B. Multi-omics assessment of dilated cardiomyopathy using non-negative matrix factorization. PLoS One. 2022 Aug 18;17(8):e0272093. doi: 10.1371/journal.pone.0272093. PMID: 35980883; PMCID: PMC9387871.
Kayvanpour E, Wisdom M, Lackner MK, Sedaghat-Hamedani F, Boeckel JN, Müller M, Eghbalian R, Dudek J, Doroudgar S, Maack C, Frey N, Meder B. VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. Int J Mol Sci. 2022 Jun 30;23(13):7327. doi: 10.3390/ijms23137327. PMID: 35806332; PMCID: PMC9267100.
Wiedmann F, De Simone R, Rose P, Karck M, Gorenflo M, Frey N, Schmidt C. Case report of an S-ICD implantation for secondary prevention in a patient with complex congenital heart disease, dextrocardia, and situs solitus. Eur Heart J Case Rep. 2022 Jun 28;6(7):ytac253. doi: 10.1093/ehjcr/ytac253. PMID: 35821967; PMCID: PMC9269672.
Selected Previous Publications
1. Zhu, C., Wu, J., Sun, H., Briganti, F., Meder, B., Wei, W. & Steinmetz, L. M. Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes, Nat Commun. 12, 4203, 2021
2. Schott, J., Reitter, S., Lindner, D., Grosser, J., Bruer, M., Shenoy, A., Geiger, T., Mathes, A., Dobreva, G. & Stoecklin, G. Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density, Nat Methods. 18, 1068-1074, 2021
3. Marion-Poll, L., Foret, B., Zielinski, D., Massip, F., Attia, M., Carter, A. C., Syx, L., Chang, H. Y., Gendrel, A. V. & Heard, E. Locus specific epigenetic modalities of random allelic expression imbalance, Nat Commun. 12, 5330, 2021
4. Schneider, J. W., Oommen, S., Qureshi, M. Y., Goetsch, S. C., Pease, D. R., Sundsbak, R. S., Guo, W., Sun, M., Sun, H., Kuroyanagi, H., Webster, D. A., Coutts, A. W., Holst, K. A., Edwards, B. S., Newville, N., Hathcock, M. A., Melkamu, T., Briganti, F., Wei, W., Romanelli, M. G., Fahrenkrug, S. C., Frantz, D. E., Olson, T. M., Steinmetz, L. M., Carlson, D. F., Nelson, T. J. & Wanek Program Preclinical, P. Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs, Nat Med. 26, 1788-1800, 2020
5. Kuhn, T. C., Knobel, J., Burkert-Rettenmaier, S., Li, X., Meyer, I. S., Jungmann, A., Sicklinger, F., Backs, J., Lasitschka, F., Muller, O. J., Katus, H. A., Krijgsveld, J. & Leuschner, F. Secretome Analysis of Cardiomyocytes Identifies PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) as a Novel Player in Cardiac Remodeling After Myocardial Infarction, Circulation. 141, 1628-1644, 2020
6. Trendel, J., Schwarzl, T., Horos, R., Prakash, A., Bateman, A., Hentze, M. W. & Krijgsveld, J. The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest, Cell. 176, 391-403 e19, 2019
7. Seeger, T., Shrestha, R., Lam, C. K., Chen, C., McKeithan, W. L., Lau, E., Wnorowski, A., McMullen, G., Greenhaw, M., Lee, J., Oikonomopoulos, A., Lee, S., Yang, H., Mercola, M., Wheeler, M., Ashley, E. A., Yang, F., Karakikes, I. & Wu, J. C. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay, Circulation. 139, 799-811, 2019
8. Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., Zhang, J. Z., Chen, X., Gil, I. P., Ameen, M., Sallam, K., Rhee, J. W., Churko, J. M., Chaudhary, R., Chour, T., Wang, P. J., Snyder, M. P., Chang, H. Y., Karakikes, I. & Wu, J. C. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy, Nature. 572, 335-340, 2019
9. Jebessa, Z. H., Shanmukha, K. D., Dewenter, M., Lehmann, L. H., Xu, C., Schreiter, F., Siede, D., Gong, X. M., Worst, B. C., Federico, G., Sauer, S. W., Fischer, T., Wechselberger, L., Muller, O. J., Sossalla, S., Dieterich, C., Most, P., Grone, H. J., Moro, C., Oberer, M., Haemmerle, G., Katus, H. A., Tyedmers, J. & Backs, J. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4, Nat Metab. 1, 1157-1167, 2019
10. Horos, R., Buscher, M., Kleinendorst, R., Alleaume, A. M., Tarafder, A. K., Schwarzl, T., Dziuba, D., Tischer, C., Zielonka, E. M., Adak, A., Castello, A., Huber, W., Sachse, C. & Hentze, M. W. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy, Cell. 176, 1054-1067 e12, 2019
11. van den Hoogenhof, M. M. G., Beqqali, A., Amin, A. S., van der Made, I., Aufiero, S., Khan, M. A. F., Schumacher, C. A., Jansweijer, J. A., van Spaendonck-Zwarts, K. Y., Remme, C. A., Backs, J., Verkerk, A. O., Baartscheer, A., Pinto, Y. M. & Creemers, E. E. RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling, Circulation. 138, 1330-1342, 2018
12. Lehmann, L. H., Jebessa, Z. H., Kreusser, M. M., Horsch, A., He, T., Kronlage, M., Dewenter, M., Sramek, V., Oehl, U., Krebs-Haupenthal, J., von der Lieth, A. H., Schmidt, A., Sun, Q., Ritterhoff, J., Finke, D., Volkers, M., Jungmann, A., Sauer, S. W., Thiel, C., Nickel, A., Kohlhaas, M., Schafer, M., Sticht, C., Maack, C., Gretz, N., Wagner, M., El-Armouche, A., Maier, L. S., Londono, J. E. C., Meder, B., Freichel, M., Grone, H. J., Most, P., Muller, O. J., Herzig, S., Furlong, E. E. M., Katus, H. A. & Backs, J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway, Nat Med. 24, 62-72, 2018
13. Gilsbach, R., Schwaderer, M., Preissl, S., Gruning, B. A., Kranzhofer, D., Schneider, P., Nuhrenberg, T. G., Mulero-Navarro, S., Weichenhan, D., Braun, C., Dressen, M., Jacobs, A. R., Lahm, H., Doenst, T., Backofen, R., Krane, M., Gelb, B. D. & Hein, L. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo, Nat Commun. 9, 391, 2018
14. Cusanovich, D. A., Reddington, J. P., Garfield, D. A., Daza, R. M., Aghamirzaie, D., Marco-Ferreres, R., Pliner, H. A., Christiansen, L., Qiu, X., Steemers, F. J., Trapnell, C., Shendure, J. & Furlong, E. E. M. The cis-regulatory dynamics of embryonic development at single-cell resolution, Nature. 555, 538-542, 2018
15. Meder, B., Haas, J., Sedaghat-Hamedani, F., Kayvanpour, E., Frese, K., Lai, A., Nietsch, R., Scheiner, C., Mester, S., Bordalo, D. M., Amr, A., Dietrich, C., Pils, D., Siede, D., Hund, H., Bauer, A., Holzer, D. B., Ruhparwar, A., Mueller-Hennessen, M., Weichenhan, D., Plass, C., Weis, T., Backs, J., Wuerstle, M., Keller, A., Katus, H. A. & Posch, A. E. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure, Circulation. 136, 1528-1544, 2017
16. Turei, D., Korcsmaros, T. & Saez-Rodriguez, J. OmniPath: guidelines and gateway for literature-curated signaling pathway resources, Nat Methods. 13, 966-967, 2016
17. Eden, M., Meder, B., Volkers, M., Poomvanicha, M., Domes, K., Branchereau, M., Marck, P., Will, R., Bernt, A., Rangrez, A., Busch, M., German Mouse Clinic, C., Hrabe de Angelis, M., Heymes, C., Rottbauer, W., Most, P., Hofmann, F. & Frey, N. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression, Nat Commun. 7, 11317, 2016
18. Junion, G., Spivakov, M., Girardot, C., Braun, M., Gustafson, E. H., Birney, E. & Furlong, E. E. A transcription factor collective defines cardiac cell fate and reflects lineage history, Cell. 148, 473-86, 2012