A09: Random monoallelic gene expression in inherited cardiomyopathies

Genes displaying random monoallelic expression (RME) are often associated with autosomal dominant disorders including cardiomyopathies. However, the impact of RME in heart diseases and the epigenetic mechanisms underlying RME are largely unexplored. Here, we propose to gain mechanistic understanding of how RME is regulated in the context of inherited cardiomyopathies using both genomics approaches and genetic engineering. An understanding of the epigenetic control of RME genes could enable the development of ‘epidrug’ treatments in heart pathologies.