RNA biology, RNA-binding proteins, riboregulation, metabolism, molecular mechanisms of disease

2023 The Centenary Award, The Biochemical Society, London, United Kingdom

2021 – Advisor of the RNA Society Diversity, Inclusion & Equity (DIE) Working Group

2020 RNA Society Lifetime Achievement Award

2018 Elected International Honorary Member, American Academy of Arts and Sciences

2018 Ilse and Helmut Wachter Award, Medical University of Innsbruck, Austria

2017 Doctor of Science, honoris causa, Australia National University, Canberra, Australia

2016 Heidelberg Molecular Life Sciences Investigator Award

2016 Elected Member, Academia Europaea (MAE)

2016 Elected Corresponding Member (FAA), Australian Academy of Science

2015 Feodor Lynen Medal and Lecture, German Society for Biochemistry and Molecular Biology

2015 Elected Director, The RNA Society, (2016–2018)

2013 – Director, European Molecular Biology Laboratory (EMBL), Heidelberg

2011 European Research Council (ERC) Advanced Grant

2007 Lautenschläger Research Prize, Heidelberg University, Heidelberg

2006 Elected Member German Academy of Sciences Leopoldina (ML)

2002 – Co-Founder and Director, Molecular Medicine Partnership Unit, Heidelberg

2000 Gottfried Wilhelm Leibniz Prize of the German Research Foundation (DFG)

1997 Elected member of “European Molecular Biology Organization”

1985 Deutsche Forschungsgemeinschaft: Postdoctoral fellowship

1) Huppertz I, Perez-Perri JI, Mantas P, Sekaran T, Schwarzl T, Russo F, Ferring-Appel D, Dimitrova-Paternoga L, Kafkia E, Hennig J, Neveu PA, Patil K and Hentze MW. Riboregulation of Enolase 1 Activity Controls Glycolysis and Embryonic Stem Cell Differentiation. Mol. Cell, in press, 2022

2) Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C and Hentze MW. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy. Cell 176:1054-67, 2019

3) Hentze MW, Castello A, Schwarzl T and Preiss T. A brave new world of RNA-binding proteins. Nat Rev Mol Cell Biol 19:327-41, 2018

4) Castello A, Fischer B, Frese CK, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J and Hentze MW. Comprehensive Identification of RNA-Binding Domains in Human Cells. Mol Cell 63:696-710, 2016

5) Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J & Hentze MW. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149:1393-406, 2012