Prof. Dr. Jörg Heineke

Director, Full Professor (W3)

Department of Cardiovascular Physiology

European Center for Angioscience (ECAS)

Medical Faculty Mannheim, Heidelberg University

joerg.heineke@medma.uni-heidelberg.de

  • • Intercellular communication in the myocardium in physiology and disease

    • Post-transcriptional mechanisms of cardiomyocyte hypertrophy

    • Interorgan communication and comorbidities in heart failure

  • 2021 Chairman of the Working group 8 of the German Cardiac Society

    2019 Head of the IRTG School of Angioscience (in the CRC1366)

    2019 Member of the elected council of the Medical Faculty Mannheim

    2019 Deputy Speaker of the DZHK partner site Heidelberg/Mannheim

    2012 Heisenberg professorship (from the German Research Foundation, DFG) for Experimental Cardiology

    2011 Sir Hans Krebs Prize (endowed by Ernst-August Schrader)

  • 1) Zwadlo C*, Schmidtmann E*, Szaroszyk M*, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J§. Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation. 2015 Mar 24;131(12):1071-81.

    2) Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J§. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res. 2017 Jan 6;120(1):66-77. doi: 10.1161/CIRCRESAHA.116.309398.

    3) Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med. 2019 Oct; 11 (10) 30:e10018. doi: 10.15252/emmm.201810018.

    4) Malek Mohammadi M, Abouissa A, Heineke J. A surgical mouse model of neonatal pressure overload by transverse aortic constriction. Nat Protoc. 2021 Feb;16(2):775-790. doi: 10.1038/s41596-020-00434-9.

    5) Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund G, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Macedo TG, Tortola CP, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Amouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J. Skeletal muscle derived Musclin protects the heart during pathological overload. Nature Communications (2022), 10;13(1):149. doi: 10.1038/s41467-021-27634-5.