Prof. Dr. Georg Stoecklin

Head of the Department of Biochemistry

Mannheim Institute for Innate Immunoscience (MI3)

Medical Faculty Mannheim of Heidelberg University

Ludolf-Krehl-Straße 13-17, 68167 Mannheim

+49-621-383-71444

georg.stoecklin@medma.uni-heidelberg.de

  • Control of mammalian mRNA translation and turnover, RNA-binding proteins, post-transcriptional control of gene expression, stress responses, macrophage biology

  • 2021- Director of the Core Facility Platform Mannheim (CFPM)

    2019- Co-director of the Mannheim Institute for Innate Immunoscience (MI3)

    2012-2014 Speaker of the Cellnetworks Emerging Collaborative Topic 5 "Non-coding RNAs as versatile regulators of cellular processes", Heidelberg University

    2006-2015 Junior Group Leader, German Cancer Research Center (DKFZ), Heidelberg

    2004 Promoted Speaker Award, Gordon Research Conference, Andover, NH, USA

    2003 Travel Award, RNA-Society, Meeting on AU-rich elements, Florence, Italy

    2002-2004 Swiss National Science Foundation, Postdoctoral Fellowship Award

    2001 Paul Basset Prize, European Cancer Center Meeting, Strasbourg, France

    1997-2000 Swiss Academy of Medical Sciences, MD-PhD Fellowship Award

    1996 Medical Faculty Prize, University of Basel, Switzerland

    1990 Prix Ernest Leuba, University of Neuchâtel, Switzerland

  • 1) Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, Lebedeva S, Schweiggert J, Schott J, Valkov E, Stoecklin G. RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. Nat Commun 2021;12:7175.

    2) Schott J, Reitter S, Lindner D, Grosser J, Bruer M, Shenoy A, Geiger T, Mathes A, Dobreva G, Stoecklin G. Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Nat Methods 2021;18:1068-1074.

    3 Haneke K, Schott J, Lindner D, Kruse Hollensen A, Kroun Damgaard C, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. CDK1 couples proliferation with protein synthesis. J Cell Biol 2020;219:e201906147.

    4) Sharma S, Poetz F, Bruer M, Ly-Hartig TBN, Schott J, Séraphin B, Stoecklin G. Acetylation-Dependent Control of Global Poly-A RNA Degradation by CBP/p300 and HDAC1/2. Mol Cell 2016;63:927-38.

    5) Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G. Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs. Cell 2013;153:869-81.