Junior Research Group Leader

Institute of Experimental Cardiology

Im Neuenheimer Feld 669, 69120 Heidelberg

+49-6221-56-310130

arica.beisaw@med.uni-heidelberg.de

  • molecular and cellular mechanisms of cardiac regeneration and repair in zebrafish and mouse models, cardiomyocyte regeneration, intercellular interactions, transcription factors and epigenetics, chromatin regulation

  • 2022 Co-chair of the GRS for Cardiac Regulatory Mechanisms

    2022 Shared Expertise Project Grant (co-PI), DZHK

    2021 Flexible Funds Grant (co-PI), CPI, German Cluster of Excellence

    2021 Promotion of Women Scientists Grant, DZHK

    2020 NRSA Individual Postdoctoral Fellowship (F32HL143839), NIH

  • 1) Beisaw A*, Kuenne C, Guenther S, Dallmann J, Wu CC, Bentsen M, Looso M, Stainier DYR*. AP-1 contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during zebrafish heart regeneration. Circ Res 126: 1760-1778, 2020 *co-corresponding authors

    2) Fukuda R, Gunawan F, Ramadass R, Beisaw A, Konzer A, Mullapudi ST, Gentile A, Maischein HM, Graumann J, Stainier DYR. Mechanical forces regulate cardiomyocyte maturation via the Vinculin-Slingshot1-Cofilin axis. Dev Cell 51: 62-77, 2019

    3) Marass M*, Beisaw A*, Gerri C, Luzzani F, Fukuda N, Guenther S, Kuenne C, Reischauer S, Stainier DYR. Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish. Development 146: dev173427, 2019 *co-first authors

    4) Beisaw A, Koch F, Tsaytler P, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P. BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep 19: 118-134, 2018

    5) Fukuda R, Gunawan F, Beisaw A, Jimenez-Amilburu V, Maischein HM, Kostin S, Kawakami K, Stainier DYR. Proteolysis regulates cardiomyocyte maturation and tissue integration. Nat Commun 8: 14495, 2017